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SB is a serum protein that is thought to aid in the functioning of neurons early in life, and it is present only in the brain. In studies over the past several years, the SB protein has been found to be transiently increased in the bloodstream after mild TBI Dash et al, , suggesting that the blood brain barrier can be compromised in traumatic brain injury, including concussion. It is semi-permeable, allowing some materials to cross, but preventing others from crossing. When the SB protein becomes present in the bloodstream, the body may react to it as a foreign invader and release auto-antibodies to attack it. The antibodies can then leak into the brain through the weakened blood-brain barrier where they are thought to attack brain tissue.
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